Poster Session

This poster session will showcase some of the cutting edge research on continuous manufacturing being developed at MIT, the University of Strathclyde (Scotland), and the University of Cambridge (England). The topics cover a broad range of research on continuous manufacturing—from the supply chain, to new synthesis pathways and processes for API manufacturing, to novel crystallization, tablet forming processes, as well as modeling of various processes. The work presented displays some of the advanced research that is rapidly going from idea conception, to proof of concept, to process maturation, and subsequent translation into pharmaceutical production.

1. Re-configuring the Pharma Supply Chain End-to-End through Continuous Manufacturing

Tomás Harrington
Authors: Tomás Harrington, Leila Alinaghian, Jagjit Singh Srai, Mike Gregory
PI: Mike Gregory

2. Flow Systems for Reaction Optimization and Scale-up

Brandon Reizman
Authors: Brandon J. Reizman, Stephen C. Born, Yanjie Zhang, Lu Yang, Jonathan P. McMullen, Klavs F. Jensen
PI: Klavs Jensen

3. Catalyst Recycle in Flow

Everett O’Neal
Authors: Everett O'Neal, Xiaoying Liu, Pengfei Li, Jason Moore, Klavs Jensen
PI: Klavs Jensen

4. Generation of cyclic carbonate using sequential flow system from CO2 and olefin

Jie Wu
Authors: Jie Wu, T. Alan Hatton, Timothy F. Jamison
PI: Tim Jamison

5. Continuous-Flow Synthesis of Functionalized Phenols by Aerobic Oxidation of Organomagnesium Reagents

Zhi He
Authors: Zhi He, Timothy F. Jamison
PI: Tim Jamison

6. Continuous-Flow Approaches Toward 1-Substituted Benzotriazoles and Trifluoromethylated (Hetero)Aromatic Compounds

Mao Chen
Authors: Mao Chen, Stephen L. Buchwald
PI: Stephen Buchwald

7. Design Approach for Moving from Batch to Continuous: Oscillatory Baffled Crystalliser (OBC) Technology

Thomas McGlone
Authors: Thomas McGlone, Naomi Briggs, Vishal Raval, Craig Johnston, Alastair Florence
PI: Alastair Florence

8. Continuous Crystallization and Polymorph Dynamics in the L-glutamic Acid System

Chris Lai
Authors: Tsai-Ta C. Lai, Steven Ferguson, Laura Palmer, Bernhardt L. Trout, Allan S. Myerson
PI: Allan Myerson

9. Purification by Impurity Complexation in Solution

Cameron Weber
Authors: Cameron C. Weber, Geoffrey P. F. Wood, Andreas J. Kunov-Kruse, Douglas E. Nmagu, Bernhardt L. Trout, Allan S. Myerson
PI: Allan Myerson

10. Multistage Continuous MSMPR Crystallizer with Solid Recycle

Jicong Li
Authors: Jicong Li, Bernhardt L. Trout, Allan S. Myerson
PI: Allan Myerson

11. Ionic liquids for purification of APIs

Andreas Kunov-Kruse
Authors: Andreas J. Kunov-Kruse, Cameron Weber, Allan Myerson
PI: Allan Myerson

12. Biocompatible Composite Hydrogels Laden with Crystalline Active Pharmaceutical Ingredient of Controlled Size and Loading

Marcus O'Mahony
Authors: Marcus O’Mahony, H.Burak Eral, Robert Shaw, Bernhardt L. Trout, Allan S. Myerson, Patrick S. Doyle
PI: Allan Myerson

13. Heterogeneous Nucleation of API's on Biocompatible Polymer Films: Applications in Continuous Pharmaceutical Manufacturing

Li Tan
Authors: Li Tan, Rachel M. Davis, Allan S. Myerson, Bernhardt L. Trout
PI: Bernhardt Trout

14. Mechanistic Studies of Pharmaceutical Crystal Nucleation using Computer Simulation

Mike Belluci
Authors: Michael Bellucci, Bernhardt L. Trout
PI: Bernhardt Trout

15. Computer simulation of crystallization of pharmaceutical compounds (paracetamol)

Fahimeh Baftizadeh
Authors: Fahimeh Baftizadeh, Michael Bellucci, Bernhardt L. Trout
PI: Bernhardt Trout

16. Startup Optimization of Crystallization Units in a Continuous Pharmaceutical Plant

Ali Sahlodin
Authors: Ali M. Sahlodin, Paul Barton
PI: Paul Barton

17. Modeling and design of layer/falling film solution crystallization

Lifang Zhou
Authors: Lifang Zhou, Min Su, Steven T. Ferguson, Yongsuk Youn, Brahim Benyahia, Aniruddh Singh, Paul I. Barton, Bernhardt L. Trout, Allan S. Myerson, Richard D. Braatz
PI: Richard Bratz

18. Establishment of continuous crystallisation of lactose using process analytical technologies

Humera Siddique
Authors: Humera Siddique, Ian Houson, John Mack, Alastair Florence
PI: Alastair Florence

19. Development of continuous crystallisation processes to achieve better control over particulate product attributes

Anna Jawor-Baczynska
Authors: Anna Jawor-Baczynska, Jan Sefcik, Ulrich Schacht
PI: Jan Sefcik

20. A Continuous Roll-Bonding Process for Pharmaceutical Manufacturing

Nikhil Padhye
Authors: Nikhil Padhye, Bernhardt L. Trout, Alexander H. Slocum, David M. Parks
PI: Bernhardt Trout

21. Reachable Space of Dynamical Systems: A Level Set Approach

Arash Komaee
Authors: Arash Komaee, Stuart M. Harwood, Paul I. Barton
PI: Paul Barton

22. Dynamic modeling and control of a pharmaceutical thin-film drying process

Ali Mesbah
Authors: Ali Mesbah, Richard D. Braatz.
PI: Richard Bratz

23. Free Surface Electrospinning on a Continuous Manufacturing Platform

Keith Jensen
Authors: Indrani Bhattacharyya, Rachael C. Hogan, Keith D. Jensen, Gregory C. Rutledge
PI: Greg Rutledge