This poster session will showcase some of the cutting edge research on continuous manufacturing being developed at MIT, the University of Strathclyde (Scotland), and the University of Cambridge (England). The topics cover a broad range of research on continuous manufacturing—from the supply chain, to new synthesis pathways and processes for API manufacturing, to novel crystallization, tablet forming processes, as well as modeling of various processes. The work presented displays some of the advanced research that is rapidly going from idea conception, to proof of concept, to process maturation, and subsequent translation into pharmaceutical production.
1. Re-configuring the Pharma Supply Chain End-to-End through Continuous Manufacturing
Tomás Harrington
tsh32@cam.ac.uk
Authors: Tomás Harrington, Leila Alinaghian, Jagjit Singh Srai, Mike Gregory
PI: Mike Gregory
2. Flow Systems for Reaction Optimization and Scale-up
Brandon Reizman
reizman@mit.edu
Authors: Brandon J. Reizman, Stephen C. Born, Yanjie Zhang, Lu Yang, Jonathan P. McMullen, Klavs F. Jensen
PI: Klavs Jensen
3. Catalyst Recycle in Flow
Everett O’Neal
eoneal@mit.edu
Authors: Everett O'Neal, Xiaoying Liu, Pengfei Li, Jason Moore, Klavs Jensen
PI: Klavs Jensen
4. Generation of cyclic carbonate using sequential flow system from CO2 and olefin
Jie Wu
jasonwu@mit.edu
Authors: Jie Wu, T. Alan Hatton, Timothy F. Jamison
PI: Tim Jamison
5. Continuous-Flow Synthesis of Functionalized Phenols by Aerobic Oxidation of Organomagnesium Reagents
Zhi He
zhihe@mit.edu
Authors: Zhi He, Timothy F. Jamison
PI: Tim Jamison
6. Continuous-Flow Approaches Toward 1-Substituted Benzotriazoles and Trifluoromethylated (Hetero)Aromatic Compounds
Mao Chen
chemc5h5@mit.edu
Authors: Mao Chen, Stephen L. Buchwald
PI: Stephen Buchwald
7. Design Approach for Moving from Batch to Continuous: Oscillatory Baffled Crystalliser (OBC) Technology
Thomas McGlone
Thomas.mcglone@strath.ac.uk
Authors: Thomas McGlone, Naomi Briggs, Vishal Raval, Craig Johnston, Alastair Florence
PI: Alastair Florence
8. Continuous Crystallization and Polymorph Dynamics in the L-glutamic Acid System
Chris Lai
chrislai@mit.edu
Authors: Tsai-Ta C. Lai, Steven Ferguson, Laura Palmer, Bernhardt L. Trout, Allan S. Myerson
PI: Allan Myerson
9. Purification by Impurity Complexation in Solution
Cameron Weber
weber_c@mit.edu
Authors: Cameron C. Weber, Geoffrey P. F. Wood, Andreas J. Kunov-Kruse, Douglas E. Nmagu, Bernhardt L. Trout, Allan S. Myerson
PI: Allan Myerson
10. Multistage Continuous MSMPR Crystallizer with Solid Recycle
Jicong Li
jicongli@mit.edu
Authors: Jicong Li, Bernhardt L. Trout, Allan S. Myerson
PI: Allan Myerson
11. Ionic liquids for purification of APIs
Andreas Kunov-Kruse
akunovkr@mit.edu
Authors: Andreas J. Kunov-Kruse, Cameron Weber, Allan Myerson
PI: Allan Myerson
12. Biocompatible Composite Hydrogels Laden with Crystalline Active Pharmaceutical Ingredient of Controlled Size and Loading
Marcus O'Mahony
omahonym@mit.edu
Authors: Marcus O’Mahony, H.Burak Eral, Robert Shaw, Bernhardt L. Trout, Allan S. Myerson, Patrick S. Doyle
PI: Allan Myerson
13. Heterogeneous Nucleation of API's on Biocompatible Polymer Films: Applications in Continuous Pharmaceutical Manufacturing
Li Tan
tanli@mit.edu
Authors: Li Tan, Rachel M. Davis, Allan S. Myerson, Bernhardt L. Trout
PI: Bernhardt Trout
14. Mechanistic Studies of Pharmaceutical Crystal Nucleation using Computer Simulation
Mike Belluci
bellucci@mit.edu
Authors: Michael Bellucci, Bernhardt L. Trout
PI: Bernhardt Trout
15. Computer simulation of crystallization of pharmaceutical compounds (paracetamol)
Fahimeh Baftizadeh
fbafti@mit.edu
Authors: Fahimeh Baftizadeh, Michael Bellucci, Bernhardt L. Trout
PI: Bernhardt Trout
16. Startup Optimization of Crystallization Units in a Continuous Pharmaceutical Plant
Ali Sahlodin
sahlodin@mit.edu
Authors: Ali M. Sahlodin, Paul Barton
PI: Paul Barton
17. Modeling and design of layer/falling film solution crystallization
Lifang Zhou
lfzhou@mit.edu
Authors: Lifang Zhou, Min Su, Steven T. Ferguson, Yongsuk Youn, Brahim Benyahia, Aniruddh Singh, Paul I. Barton, Bernhardt L. Trout, Allan S. Myerson, Richard D. Braatz
PI: Richard Bratz
18. Establishment of continuous crystallisation of lactose using process analytical technologies
Humera Siddique
Humera.siddique@strath.ac.uk
Authors: Humera Siddique, Ian Houson, John Mack, Alastair Florence
PI: Alastair Florence
19. Development of continuous crystallisation processes to achieve better control over particulate product attributes
Anna Jawor-Baczynska
Anna.jawor-baczynska@strath.ac.uk
Authors: Anna Jawor-Baczynska, Jan Sefcik, Ulrich Schacht
PI: Jan Sefcik
20. A Continuous Roll-Bonding Process for Pharmaceutical Manufacturing
Nikhil Padhye
npdhye@gmail.com
Authors: Nikhil Padhye, Bernhardt L. Trout, Alexander H. Slocum, David M. Parks
PI: Bernhardt Trout
21. Reachable Space of Dynamical Systems: A Level Set Approach
Arash Komaee
akomaee@mit.edu
Authors: Arash Komaee, Stuart M. Harwood, Paul I. Barton
PI: Paul Barton
22. Dynamic modeling and control of a pharmaceutical thin-film drying process
Ali Mesbah
amesbah@mit.edu
Authors: Ali Mesbah, Richard D. Braatz.
PI: Richard Bratz
23. Free Surface Electrospinning on a Continuous Manufacturing Platform
Keith Jensen
kdj@mit.edu
Authors: Indrani Bhattacharyya, Rachael C. Hogan, Keith D. Jensen, Gregory C. Rutledge
PI: Greg Rutledge